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Meanings and history of the name Sixtus

From Greek, meaning "polished". It was originally translated into Latin as "Xystus", later evolving into the present form.

Famous real-life people named Sixtus

Five popes took this name, most notably Sixtus IV, the sponsor of Michelangelo. The Sistine Chapel is named for him.
Sixtus of Siena, Catholic theologian
Prince Sixtus of Bourbon-Parma, World War I intermediary and negotiator
Sixtus was Senator Edmund Muskie's middle name.

Sixtus in song, story & screen